[AtomicLabMonkey]

I have never seen a lug nut loosen up because of anti-seize application. On my cars I give the studs a good wire-brushing and put a *light* coating of anti-seize on. The real danger when there is any lubricant on a fastener is over-torquing, since it lowers the friction coefficient on the threads. Most manufacturers spec a range of acceptable torque for lug nuts, like 80-100 lb*ft, or something like that - so if I'm using anti-seize I torque to the low end of their acceptable range instead of the high end.